Yearly mammogram for most peri and post-menopausal women show a reading of “dense or very dense” reading and to get further studies or to repeat studies in the next year.
Dense breast by mammography means breast glandular cells and supporting stromal collagen fibrous are stimulated by human estrogens- estradiol the most powerful, estriol, and estrone. The density gives the breast shape and firmness and able to withstand gravity and facilitates lactation with pregnancy and delivery.
Breast Glands + Fibrous Stroma
Persistent Non Involuting Breast Epithelium and gland Correlates with Radiological Increasing Dense Breasts
With increasing age especially from 45 to 60 and further, the breast density should decrease, and glandular tissues and cells should “Involute”. It is not normal for persistent breast density from the influence of human estrogen, a composite of estradiol, estriol, and estrones after childbearing years.
Breast density at ages 45-60 and on is at risk for breast cancer development at 30-50% increase. Density is influenced by estradiol, estriol and estrone.
KJ Chang and de Ligniere 1995 from France and Taiwan and Jason Carroll of from Cambridge UK 2016 have shown that Progesterone the other powerful female hormone can counteract the effects of estradiol estrogens.
Carroll showed the intricate biochemistry of downregulation of “Micronized human identical progesterone on estradiol receptors on a cellular level. Chang and de Ligniere showed that a Micronized progesterone topical cream applied to the breast prior to biopsy showed downregulation of estrogen receptors in human subjects.
And more recently the biochemical study confirms that progesterone can down regulate estradiol, estrione.
Dr. PJ Huang of Taiwan, Dr. David Zava of USA and Dr. Ralph Highnam of New Zealand have been working on the project to Study selected women with high breast density to test out the hypothesis that the group with highest breast “density” can decrease the density and decrease the risk of breast cancer development.
High volumetric breast density is associated with a higher risk for breast cancer in postmenopausal women. Persistent breast density extending to post-menopausal period is probably related to Estrogen dominance over progesterone as a main factor and therefore higher chances of breast cancer development. Park IH, Ann Surg Oncol 2014, 21 : 4124-4132
Other factors from a nutritional standpoint also effect breast density and TDLU or persistent non involuting breast glands and stroma. The more sugar and carbohydrates and alcohol you consume the more chance of having dense breast. Coffee makes more breast cysts. PET scans of breast cancer show also that breast cancer rely of sugar as a primary source of energy and “fuel” to multiply.
Because consumption of more sugars and carbohydrate increase breast density, Dr. Pamela Goodwin of the University of Toronto observed from the data of the Women’s Health Initiative study that women with breast cancer did not progress as quickly when they were on an anti-diabetes medication Metformin.
One side effect of oral metformin intense abdominal discomfort but by using metformin 200mg / into 1 milliliter cream, one can avoid the oral problems and bypass liver metabolism by using a compounded.
Another clue on the importance of Progesterone Receptor (PR) and progesterone is the clinical data on prognosis of patients cancer time of recurrence and metastasis management. The clinical outcome data showing that breast cancer with low progesterone receptors is a poor prognosis for recurrence of disease with metastasis.
Lastly, a table is provided that gives the key characteristics of the patients studied.
A post hoc analysis suggests that not only negative PR but also very low PR predicts recurrence. The supplementaryMaterial, available at Annals of Oncology online presents a discussion of the findings of very low PR. We suggest
that in the future, using the rule that grade 1 breast cancers with a PR percent < 3%–5% not be considered low risk in our algorithms.
A discussion of low PR percentage staining as a marker of a poor prognosis is given. These findings support our recommendation that the AAMC Model’s definition for low risk be changed to grade 1 and PR >3-5%.